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    한국섬유공학회지, Vol.56, No.1, pp. 65-77, 2019
    아토피 피부염 모델인 NC/Nga 실험쥐에 세라마이드 함유 3차원 섬유 구조체가 미치는 효과
    Effect of the Ceramide-Contained 3-D Fiber Matrix on Atopic Dermatitis in the NC/Nga Mice
     
    양광웅 · 노용환 · 김의화 · 이승훈 · 김찬
     
    In this study, we worked on a fiber structure containing ceramide and evaluated its impacts on the wet and dry-type atopic caused by the atopic dermatitis (AD) ointment and TNCB in the NC/Nga Mice. We also measured and evaluated the ability to control the enzyme activity in the DNA and RNA levels using the enzyme-linked immunosorbent assay analysis, sensory evaluation, TWEL (transepidermal water loss) and moisture content measurements. We conducted a statistical analysis to assess the improvements in AD and the mitigation between the control groups using a histopathological analysis and the Western blotting evaluation. The amount of TWEL in the TNCB group, which is a wet-type atopicinduced group, was significantly higher than that in the dry-type AD-induced group. A serological analysis revealed a significant reduction of the Immunoglobulin E level in all the wearing groups (M-1, M2, C-1, C-2) compared to the negative control on the 35th day of the experiment. It was confirmed that the ceramide-contained 3-D fiber structure recovers and improves the skin barrier function among the Nc/Nga mice. The NC/Nga mice in-vivo results of the ceramide-containing 3-D fiber matrix are applicable in the design of customized skin care garments effective in relieving and improving the dry and wet-type AD.
     
    Keywords : atopic dermatitis, ceramide, 3-D fiber matrix, NC/Nga mice, TWEL
    DOI : https://doi.org/10.12772/TSE.2019.56.065
     
    Full text(PDF)  아토피 피부염 모델인 NC/Nga 실험쥐에 세라마이드 함유 3차원 섬유 구조체가 미치는 효과